Dave, I'm a big guy also. I'm about 6' now. Over the years I've lost 2" in height and I'm a little over 300lbs. I carry a Kahr PM45 in a Kydex IWB tuckable holster that I made. I find that a IWB holster works best for me. Usually carry it in my 3:00 to 4:00 position with my shirt in or out without printing. Being big a OWB holster won't work for me because it really prints bad. I also carry a BUG in my back pocket, a Kahr P380 in a wallet holster. You just need to try different methods of carry to fine the one that suites you best.
USAF Retired, CATM, SC CWP, NH NR CWP, NRA Benefactor
To preserve liberty, it is essential that the whole body of people always possess arms, and be taught alike, especially when young, how to use them... -- Richard Henry Lee, 1787