My EDC is a Glock 21. I have been carrying it for about a year now, and I love it. I haven't made any modifications to it. I did switch from IWB to OWB a few months ago and I'm much happier. I carry in a Blade-Tech Eclipse holster
Eclipse Series Holster :: OWB Belt Holsters :: Blade-Tech Industries
and the forward cant does an awesome job keeping the gun in line with my body and keeping the gun from printing.
As far as advice, all I can offer is what I have been doing myself. Shoot it. Shoot it. Shoot it.
"Never attribute to malice that which can be adequately explained by stupidity"