The hope is to deliver a bit more kinetic energy with the right defense load.
I'm actually a fan of Remington 125gr +P SJHP for carry loads. For target I couldn't give a chit...
I'd be willing to carry 158gr LRN to be honest with you... Magtech makes a good round there, dirty though.
If I shoot you, it's gonna hurt really bad... if I shoot you in the chest or face, you won't be alive too long to suffer the extreme pain, lol.
For those who fight for it, life has a flavor the protected will never know.