I carry the Glock 22 in a shoulder holster. The Glock 27 can be carried in an ankle holster, but as is the case with ankle carry in general it does take some getting used to.

I knew a fellow who could not get used to the differance in stride caused by having a gun strapped to his ankle. His solution was simple, buy another gun and ankle holster for the other leg. It made everything symetrical.