I would love to start a business, but I couldn't stomach dealing with federal regulation. So, I've thought, what if I started a business that only used Indiana resources and only sold to Indiana residents?
If people from other states wanted my products, they could always buy them second-hand after my right of first sale has lapsed, OR! I could enter into informational cooperatives with business people in other states to produce a set of similar products under similar agreements nationwide, but the products sold in Oklahoma would be made in Oklahoma from Oklahoma-derived resources by Oklahoma workers, sold to Oklahomans, and serviced in Oklahoma. Products sold in Michigan would be made in Michigan from Michigan derived resources by Michigan workers, sold to Michiganders, and serviced in Michigan.
There's actually a precedent for this. Southwest Airlines. SWA started as a purely Texas-only airline, one of the few places in the USA where you could operate an airline without crossing a state border. The founders of SWA started it to get around abiding by a whole host of noxious FAA regulations.
Since SWA didn't have to obey FAA regs, it could fly more efficiently, for cheaper, and so it was eating the other airlines' lunches on intra-Texas fares, and so airlines that flew in Texas petitioned for relief from those FAA regs as well and (real) change was had. After a while, SWA started flying across the entire American Southwest, since its way of running an airline had become common, it didn't have to make any great change itself.